Antibody Scientist - Biotechnology

Posted 03 November 2023
Salary Negotiable
Job type Full Time
Discipline Cell & Gene Therapy
Contact NameRobin Mantell

Job description

Mantell Associates is currently partnered with this Cell Therapy Biotechnology organisation, who are searching for an Antibody Scientist to join their team.

Antibody Scientist - Responsibilities:

  • Pave the way with cutting-edge research in antibody DNA synthesis, expression, purification, and characterization (e.g. stability and affinity)

  • Develop these methods into efficient, robust, and cost-effective workflows that integrate well with our BioFoundry

  • Innovate on existing methods and workflows to further decrease variance, costs, turnaround time, and/or increase throughput

  • Setup ultra-high throughput experiments for large-scale antibody characterization (e.g. Tite-Seq or AlphaSeq)

  • Utilize state-of-the-art technologies and automation to run high-throughput workflows that are fast and efficient, and generate high-quality data

  • Be the go-to antibody expert, communicating your successes, results, and challenges across our interdisciplinary team

  • Create standard operating procedures for the innovative workflows you develop

Antibody Scientist - Requirements:

  • PhD or equivalent experience in molecular biology, biochemistry, enzymology, metabolic engineering, biophysics, or related fields

  • Proven expertise in antibody expression, purification, screening and characterisation (scFvs, VHHs, etc) with in vitro and/or in vivo protein expression systems

  • In-depth experience with different protein purification techniques (e.g. affinity tag purification, protein A/G chromatography) and biophysical antibody characterization techniques (SPR, BLI, DLS, ELISA, etc.)

  • A successful track record in antibody optimization including affinity maturation, stability and aggregation determination and functional assays

  • Excitement to learn, contribute, and drive innovation in an early stage startup environment. Having an appetite for its ambiguity and fast pace

  • Hands-on experience expressing antibodies in mammalian cell systems (CHO/HEK293) preferable

  • Familiarity with in vitro display technologies (phage display, yeast display) involving library design, construction, and screening preferable

  • Working knowledge of structural biology and protein computational modeling approaches (e.g. Rosetta, Visual Molecular Dynamics, PyMol, RasMol, UCSF Chimera, Crystal Studio) preferable

  • Experience with statistical approaches and next-gen sequencing techniques (Illumina, NanoPore, PacBio) preferable

Mantell Associates is a specialist Pharmaceutical and Life Science headhunting firm. For more information on this oportunity, contact us at +44 (0)20 3854 7700.